Stereochemistry of the mammalian adenylate cyclase reaction.
نویسندگان
چکیده
Adenosine 5'-O-(1-thiotriphosphate), Sp-diastereomer, is cyclized by adenylate cyclase from bovine brain to adenosine 3',5'-cyclic phosphorothioate, Rp diastereomer, establishing inversion of configuration for this reaction. This result can most easily be explained by a direct nucleophilic attack of the 3'-OH group on alpha-phosphorus without involving a covalent enzyme intermediate.
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عنوان ژورنال:
- The Journal of biological chemistry
دوره 256 17 شماره
صفحات -
تاریخ انتشار 1981